Original Candid
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 STROMBOLI original 1950 candid behind scenes still Ingrid BERGMAN ROSSELLIN $16.99 Time Remaining: 29d 5h 31m Buy It Now for only: $16.99 |
 1957 JULIE LONDON Sexy CANDID Vintage Original Movie Photo C25 $9.99 Time Remaining: 4d 19m |
 Shirley Temple Mary Pickford Original 1944 Candid Behind Scenes Promo Photo $19.95 Time Remaining: 3d 23h 1m |
 ZAZA original 1938 candid still Claudette COLBERT Geo CUKOR Lenore ULRIC $24.99 Time Remaining: 29d 5h 32m Buy It Now for only: $24.99 |
 Suzanna Leigh original busty candid news photo 1970 Lust for a Vampire Hammer $9.99 (1 Bid) Time Remaining: 3d 23h 49m |
 JOHN LIONEL BARRYMORE Arsene Lupin Original 1930s CANDID BETWEEN SCENES $38.50 Time Remaining: 28d 13h 57m Buy It Now for only: $38.50 |
 VIRGINIA BRUCE VINTAGE 1930s NEVER BEFORE SEEN CANDID ORIGINAL PHOTOGRAPH $4.95 Time Remaining: 4d 19m |
 Ida Lupino directing with a broken foot original Candid Photo 1949 Never Fear $9.99 Time Remaining: 3d 23h 27m |
 James Bond You Only Live Twice Original 1967 Candid Photo Roald Dahl Neal $59.00 Time Remaining: 26d 20h 10m Buy It Now for only: $59.00 |
 Charlotte Rampling posing original candid DW photo by Patriarca 1969 Three $9.99 (1 Bid) Time Remaining: 3d 23h 15m |
 James Bond You Only Live Twice 1967 Original Candid Photo Roald Dahl Neal $59.00 Time Remaining: 26d 20h 10m Buy It Now for only: $59.00 |
 SHARON TATE ROMAN POLANSKI Candid Stamped Vintage Original Photo C75 $24.99 (1 Bid) Time Remaining: 3d 23h 29m |
 1977 RITA HAYWORTH Candid Vintage Original Movie Photo C39 $9.99 Time Remaining: 4d 5m |
 FRANCES LANGFORD Original Vintage Portrait 1938 CANDID $26.50 Time Remaining: 28d 11h 10m Buy It Now for only: $26.50 |
 1976 Oskar Werner Max Von Sydow CANDID Vintage Original Movie Photo C68 $9.99 (1 Bid) Time Remaining: 4d 1h 15m |
 ANN MARGRET ORIGINAL CANDID PHOTO VINTAGE 35MM SLIDE $19.99 Time Remaining: 27d 16h 33m Buy It Now for only: $19.99 |
 DANA ANDREWS SUPER SEXY ORIGINAL CANDID LYING DOWN ONSET AND SMOKING $9.95 (1 Bid) Time Remaining: 3d 4h 15m |
 1977 SUPERMAN Candid Ellen Bry Margot Kidder Vintage Original Movie Photo C51 $9.99 Time Remaining: 3d 23h 53m |
 SODOM GOMORRAH original 1962 back set candid still PIER ANGELI with Camera $8.99 Time Remaining: 22d 20h 3m Buy It Now for only: $8.99 |
 ROBERT TAYLOR VINTAGE ORIGINAL 1940s CANDID NEVER BEFORE SEEN PHOTOGRAPH $4.95 Time Remaining: 4d 1h 37m |
 DOUGLAS FAIRBANKS + DIRECTOR MARSHALL NEILAN ORIGINAL VINTAGE CANDID PHOTO $14.99 Time Remaining: 24d 20h 52m Buy It Now for only: $14.99 |
 ORIGINAL VINTAGE 1932 Jean Harlow Photo Red Headed Woman Candid $24.99 (1 Bid) Time Remaining: 3d 21h 20m |
 HEDY LAMARR ORIGINAL VINTAGE 1940s CANDID NEVER BEFORE SEEN PHOTOGRAPH $4.95 (1 Bid) Time Remaining: 4d 1h 33m |
 MARLON BRANDO original candid photo 1954 $48.00 Time Remaining: 14d 24m Buy It Now for only: $48.00 |
 PAULETTE GODDARD YOUNG IN HEART CANDID WITH PENGUINS ORIGINAL $3.95 (1 Bid) Time Remaining: 3d 4h 18m |
 Mr Mrs Wallace Beery ORIGINAL late 1920s candid lakeside with dogs $11.99 Time Remaining: 28d 12h 20m Buy It Now for only: $11.99 |
 ALAN LADD VINTAGE 40s NEVER SEEN CANDID ORIGINAL PHOTO IN WWII MILITARY UNIFORM $4.95 (1 Bid) Time Remaining: 4d 17m |
 Gail Russell in court original candid news portrait photo 1956 $9.99 (1 Bid) Time Remaining: 3d 23h 20m |
 SUPERB Original Candid ALFRED HITCHCOCK CANDID PHOTO 8x10 Looks Like Rain TWA $69.00 Time Remaining: 5d 20h 24m Buy It Now for only: $69.00 |
 DESI ARNAZ VINTAGE 1930s NEVER BEFORE SEEN CANDID ORIGINAL PHOTO TAKEN IN LA $6.50 (2 Bids) Time Remaining: 4d 13m |
 Original Liz Elizabeth Taylor Candid Photos $45.00 Time Remaining: 16h 1m Buy It Now for only: $45.00 |
 Kim Novak LOT 3 Original 60s Photo Candid Bahamas Film Festival $19.95 (1 Bid) Time Remaining: 3d 21h 32m |
 Debbie Reynolds HARVE PRESNELL at FILM PREMIERE 1964 CANDID ORIGINAL PHOTO $22.50 Time Remaining: 1d 15h 48m Buy It Now for only: $24.95 |
 Original 1955 MARILYN MONROE Candid on Set THE SEVEN YEAR ITCH Photo $75.00 Time Remaining: 27d 6h 39m Buy It Now for only: $75.00 |
 A Patch of Blue Elizabeth Hartman Full Length Original Candid Portrait Photo $6.99 Time Remaining: 3d 24m |
 Original 1956 MARILYN MONROE Candid on Set BUS STOP Photo $75.00 Time Remaining: 27d 6h 32m Buy It Now for only: $75.00 |
 ORIGINAL 8X10 CANDID COLOR PHOTO OF DUDLEY MOORE LIZA MINNELLIONE OF A KIND $9.95 Time Remaining: 1d 20h 52m |
 ELIZABETH MONTGOMERY ROBERT FOXWORTH CANDID ORIGINAL 2 1 4 SLIDE TRANSPARENCY $29.99 Time Remaining: 4d 21h 59m |
 RYAN ONEAL LEIGH TAYLOR YOUNG CANDID LATE 60S PHOTO ORIGINAL TRANSPARENCY $24.99 Time Remaining: 27d 16h 37m Buy It Now for only: $24.99 |
 SYD CHAPLIN ORIGINAL CANDID ON THE ROOF OF HIS STUDIO EARLY SILENT ERA DOUBLEWT $19.95 (1 Bid) Time Remaining: 6d 4h |
 ELKE SOMMER original candid still for Grand Prix 1966 T188 $20.00 Time Remaining: 26d 23h 9m Buy It Now for only: $20.00 |
 MISCHA AUER Family ORIGINAL Vintage Agency Photo WITH CAPTION 1940 CANDID $18.50 Time Remaining: 3d 21h 22m |
 MIRAGE GREGORY PECK CANDID SIGNING AN AUTOGRAPH NICE ORIGINAL $4.99 Time Remaining: 3d 20h 29m |
 Gina Lollobrigida Original Large Doubleweight Candid 1969 Press Photo $14.95 Time Remaining: 26d 22h 26m Buy It Now for only: $14.95 |
 Edward G Robinson with Louise Fazenda original candid news photo 1955 $9.99 Time Remaining: 3d 23h 20m |
 JANIS PAIGE original candid still on resting board SILK STOCKINGS T198 $23.00 Time Remaining: 26d 23h 9m Buy It Now for only: $23.00 |
 Jennifer Jones 1949 Original Home Candid Publicity Photo $9.95 Time Remaining: 3d 22h 47m |
 JAMES STEWART VINTAGE 1930s NEVER BEFORE SEEN CANDID ORIGINAL PHOTO TAKEN IN LA $4.95 (1 Bid) Time Remaining: 4d 15m |
 GORGEOUS SEXY FAY WRAY ORIGINAL 1934 BEHIND THE SCENES HOLLYWOOD CANDID $20.00 Time Remaining: 29d 12h 15m Buy It Now for only: $20.00 |
 RICHARD GREENE VINTAGE 1930s NEVER BEFORE SEEN CANDID ORIGINAL PHOTO TAKEN IN LA $4.95 Time Remaining: 4d 11m |
 Richard Burton in his dressing room ORIGINAL 1955 candid Rains of Ranchipur $9.99 Time Remaining: 2d 13h 12m Buy It Now for only: $9.99 |
 ALAN LADD GIG YOUNG CANDID ON Movie Set ORIGINAL $9.99 Time Remaining: 3d 17h 58m |
 Barbra Streisand Groucho Marx CANDID Vintage Original Movie Photo C67 $9.99 Time Remaining: 3d 23h 37m |
 TONY CURTIS Argentina Brunetti Original 1957 Candid Photo $14.99 Time Remaining: 3d 1m Buy It Now for only: $14.99 |
 CHARLIE CHAPLIN Candid Vintage Original Movie Photo C44 $9.99 Time Remaining: 4d |
 Donna Sanborn Circa 1937 Original Photo Candid $12.00 Time Remaining: 28d 13h 9m Buy It Now for only: $12.00 |
 Richard Zanuck Roy Scheider CANDID JAWS Vintage Original Movie Photo C75 $9.99 Time Remaining: 4d 1h 7m |
 1955 Viveca Lindfors Candid Moonfleet Vintage Original Movie Photo C96 $9.99 Time Remaining: 3d 23h 11m |
 Patric Knowles 1937 Original Candid at Home Warner Bros Publicity Photo $9.95 Time Remaining: 28d Buy It Now for only: $9.95 |
 Carolyn Lee child actor riding on a boy original candid photo 1939 Paramount $9.99 Time Remaining: 3d 23h 13m |
 JEANNE CRAIN CORNEL WILDE LEAVE HER TO HEAVEN ORIGINAL VINTAGE FOX CANDID STILL $16.00 Time Remaining: 18d 17h 50m Buy It Now for only: $16.00 |
 1973 ROGER MOORE James Bond 007 CANDID Vintage Original Movie Photo C77 $9.99 Time Remaining: 4d 1h 6m |
 Tanya Roberts original busty candid news photo 1981 $9.99 Time Remaining: 3d 23h 50m |
 LEON ERROL COMEDIAN CANDID DANCING IN MOVIE STUDIO OFFICE ORIGINAL $9.99 Time Remaining: 5d 1h 18m Buy It Now for only: $9.99 |
 Doris Day Eydie Gorme CANDID Vintage Original Movie Photo C70 $9.99 Time Remaining: 3d 23h 33m |
 JANET LEIGH original candid on location still THE NAKED SPUR T182 $23.00 Time Remaining: 26d 23h 9m Buy It Now for only: $23.00 |
 REDUCED Ava Gardner studio original 1960 Angel Wore Red Candid on mat paper $5.00 Time Remaining: 2d 16h 13m Buy It Now for only: $7.00 |
 Estate of Ava Gardner original Dirk and AVA candid 1960 so in love $10.00 Time Remaining: 2d 16h 32m |
 Mari Blanchard Original 1954 On Set Behind the Scenes Candid Photo Destry $14.95 Time Remaining: 29d 23h 11m Buy It Now for only: $14.95 |
 Olga San Juan in a bustier with Tony Martin original leggy candid photo 1947 $9.99 Time Remaining: 3d 23h 37m |
 Janet Leigh 1953 Original Candid Photo $9.95 Time Remaining: 9d 20h 30m Buy It Now for only: $9.95 |
 Peter Lawford washing his car original DW candid photo 1940s $9.99 Time Remaining: 3d 23h 40m |
 Shirley MacLaine with Pete Hamill original DW candid news photo 1970s $9.99 Time Remaining: 3d 23h 45m |
 ROBERT MONTGOMERY Original Vintage CANDID Photogr 1937 $18.50 Time Remaining: 10d 20h 45m Buy It Now for only: $18.50 |
 Suzanne Pleshette and Ian McShane original candid photo 1969 If Its Tuesday $9.99 Time Remaining: 3d 23h 50m |
 OLIVE BORDEN BEAUTIFUL vintage 1926 CANDID COWGIRL ORIGINAL Stamped SILENT Photo $29.95 Time Remaining: 4d 3h 41m Buy It Now for only: $29.95 |
 LANA TURNER JOHN LUND CANDID ON SET ORIGINAL $9.99 Time Remaining: 3d 18h 2m |
 1972 Shirley MacLaine Pete Hamill Frank Yablans Candid Original Movie Photo C66 $9.99 Time Remaining: 3d 23h 38m |
 SOPHIA LOREN BEAUTIFUL HOME ORIGINAL CANDID PHOTO 5L 742E $24.99 Time Remaining: 1d 20h 39m Buy It Now for only: $24.99 |
 1977 Raul Julia Irene Worth Jon DeVries CANDID Vintage Original Photo C62 $9.99 Time Remaining: 3d 23h 42m |
 MARLENE DIETRICH original 1940 candid movie still with Tay Garnett SEVEN SINNERS $24.49 Time Remaining: 20d 22h 59m Buy It Now for only: $24.49 |
 1977 Mia Farrow Geraldine Chaplin CANDID Vintage Original Movie Photo C50 $9.99 Time Remaining: 3d 23h 54m |
 1977 Trini Lopez Lucie Arnaz CANDID Vintage Original Movie Photo C49 $9.99 Time Remaining: 3d 23h 54m |
 LINDA RONSTADT CANDID ORIGINAL 8X10 PHOTO PHOTOGRAPH 20F $14.99 Time Remaining: 1d 20h 49m Buy It Now for only: $14.99 |
 1976 TOVAH FELDSHUH Candid Yentl Vintage Original Movie Photo C46 $9.99 Time Remaining: 3d 23h 58m |
 ELAINE STRITCH PAUL HARTMAN Original CANDID 1960s $17.50 Time Remaining: 29d 15h 5m Buy It Now for only: $17.50 |
 1977 Martin Scorsese Julia Cameron CANDID Vintage Original Movie Photo C40 $9.99 Time Remaining: 4d 4m |
 1977 Barbara Carrera CANDID Vintage Original Movie Photo C38 $9.99 Time Remaining: 4d 6m |
 DONALD OCONNOR original candid photo balloons T185 $20.00 Time Remaining: 26d 23h 9m Buy It Now for only: $20.00 |
 1951 Sarag Churchill CANDID Gramercy Ghost Vintage Original Movie Photo C32 $9.99 Time Remaining: 4d 12m |
 Betty Furness Ca 1936 Original Photo Christmas Candid $15.00 Time Remaining: 28d 13h 27m Buy It Now for only: $15.00 |
 1966 Peter Sellers Britt Ekland CANDID Vintage Original Movie Photo C92 $9.99 Time Remaining: 4d 51m |
 1977 Madeline Kahn Joseph Papp CANDID Vintage Original Movie Photo C73 $9.99 Time Remaining: 4d 1h 11m |
 WESTERN COWBOY FAVE RANDOLPH SCOTT ORIGINAL 1944 HOLLYWOOD CANDID PHOTO $16.00 Time Remaining: 18d 17h 50m Buy It Now for only: $16.00 |
 1976 Gretchen Wyler Ellen Burstyn CANDID Vintage Original Movie Photo C72 $9.99 Time Remaining: 4d 1h 11m |
 SUPER HOT BROOKE SHIELDS ORIGINAL CANDID PHOTO LOT 2 $12.00 Time Remaining: 25d 12h 30m Buy It Now for only: $12.00 |
 1976 Gretchen Wyler Florence Henderson CANDID Vintage Original Movie Photo C71 $9.99 Time Remaining: 4d 1h 12m |
 1976 Sylvia Miles Richard Chamberlain Candid Vintage Original Movie Photo C69 $9.99 Time Remaining: 4d 1h 14m |
 Alan Funt Money Talks Candid Camera 1972 ORIGINAL US 8 LOBBY CARD SET $9.99 Time Remaining: 29d 23h 9m Buy It Now for only: $9.99 |
 1976 Zero Mostel Fiddler On The Roof CANDID Vintage Original Movie Photo C70 $9.99 Time Remaining: 4d 1h 12m |
Original Candid
Innovations and Opportunities in Therapeutic Vaccines: Technology platforms, key players, and early pipeline candidates
Therapeutic vaccines promise a new wave of highly potent and highly specific therapeutic agents designed to work in harmony with patients' own immune systems. Recent advances in the understanding of the human immune system and in technical capabilities have allowed vaccines to move beyond pre-emptive (prophylactic) immunization and into treatment of established diseases. In April 2010, Dendreon's Provenge became the first ever cancer vaccine to be approved by the US Food and Drug Administration (FDA), overcoming skepticism in the investment community and paving the way for a new generation of biological therapies.
This report explains what therapeutic vaccines are, how they work, and why drug developers around the world are using this approach to address everything from allergies to literally every kind of cancer. More than 70 new proprietary technologies are named and explained, with details of licensing deals and intellectual property positions.
The newest wave of drug candidates based on these technologies can be seen in more than 130 early pipeline candidates, each based on a commercial company or research institute known to have carried out preclinical and/or Phase I trials of at least one therapeutic vaccine candidate in the past year. By way of background, later stage candidates being developed by the same companies are also discussed. In total, more than 270 therapeutic vaccine candidates are identified in this report. Finally, prospects and challenges for the future of this field are discussed, with opinions from around 20 prominent industry leaders and academic researchers.
Key features of this report
• ‘Beginners guide' to vaccines and the human immune system, illustrated with original full-color diagrams, to show the potential challenges and benefits of therapeutic vaccination.
• More than 70 descriptions of proprietary technologies currently in use around the world to design, produce and administer therapeutic vaccines.
• A comprehensive guide to companies around the world that are currently developing brand new therapeutic vaccines (i.e. candidates in preclinical or Phase I clinical trials).
• Details of more than 270 specific vaccine candidates, in development by around 120 different companies and research institutes.
• Expert opinions on the opportunities, challenges and future trends in the monoclonal antibody field from around 20 industry leaders and academic researchers, over a dozen of whom were contacted directly and interviewed for this report.
Scope of this report
• Understand the basic qualities of vaccines and how these qualities translate into unique medical and commercial features for therapeutic candidates.
• Appreciate the challenges and risks of therapeutic vaccines, as well as their promise.
• Assess emerging technologies for possible investment or in-licensing.
• Identify which companies are involved in this field, and what they are doing.
• Predict the kinds of drug that may reach the market over the next ten years.
• Tailor your own company's strategies to take advantage of upcoming opportunities, such as the validation of new technologies in human patients.
Key Market Issues
• Therapeutic vaccines hold the potential to address diseases with a high unmet need for effective, i.e. markets that are currently under-penetrated.
• Much like monoclonal antibodies, the inherent specificity of vaccines may shorten drug development times and increase rates of success in preclinical and clinical trials, now that the intricacies of the human immune system are better understood.
• The recent US approval of Dendreon's personalized cancer vaccine Provenge has established a precedent and a recognized path to regulatory approval for therapeutic vaccines.
• Newer technologies target the same basic immune system processes as Provenge, but may result in cheaper and more broadly applicable therapies.
Key findings from this report
• New technical capabilities and better understanding of the human immune system has recently allowed vaccination approaches to be applied to therapeutic settings as well as prophylaxis.
• Demand for therapeutic vaccines is high, and profits from launched drugs are expected to achieve ‘blockbuster' levels (billions of US dollars per annum).
• Treatment of established diseases requires different immune reactions to protective (prophylactic) immunity, to overcome existing disease burdens and immuno-avoidance mechanisms, so immune responses must be ‘modulated' rather than just stimulated.
• Many new candidates use multiple ‘antigen' targets, or multiple variants of a single target, to address heterogeneity in both disease targets and patients' immune systems.
• Vaccine approaches can also be used to inhibit immune responses to specific ‘antigens', making them useful for treating allergies, autoimmune diseases and transplant rejection.
• Various vectors (carriers) and adjuvants (immunostimulators), each with their own benefits and drawbacks, are being used to enhance the delivery of vaccine antigens to target immune cells and to modulate the strength and type of immune responses that result.
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Candid camera - Wrong Toilet Side HQ